Table 5. Association between copy number of the sum of GSTM1/GSTT1 genes and risk of prostate cancer according to smoking, alcohol consumption, body mass index and family history of prostate cancer.
| Sum of GSTM1/GSTT1 Copy Genes | Ptrend | Pinteraction | ||||||||
| 0 | 1 | 2 | ≥3 | |||||||
| Cases/Controls | OR (CI95%) | Cases/Controls | ORa (CI95%) | Cases/Controls | ORa (CI95%) | Cases/Controls | ORa (CI95%) | |||
| Smoking | ||||||||||
| Never | 20/24 | 1.0 | 96/123 | 1.18 (0.55, 2.52) | 139/142 | 1.47 (0.70, 3.10) | 133/94 | 2.10 (0.98, 4.46) | 0.004 | 0.48 |
| Former or Current | 13/20 | 1.0 | 64/64 | 2.11 (0.88, 5.09) | 76/93 | 1.77 (0.75, 4.20) | 82/59 | 2.88 (1.20, 6.88) | 0.04 | |
| Alcohol | ||||||||||
| Never | 6/7 | 1.0 | 21/28 | 0.91 (0.23, 3.54) | 26/39 | 0.73 (0.19, 2.77) | 31/23 | 1.62 (0.42, 6.22) | 0.27 | 0.57 |
| Former or Current | 26/36 | 1.0 | 138/158 | 1.73 (0.91, 3.29) | 188/190 | 2.00 (1.06, 3.75) | 185/130 | 2.72 (1.44, 5.16) | 0.0007 | |
| BMI | ||||||||||
| <25 | 15/21 | 1.0 | 83/93 | 1.66 (0.72, 3.84) | 105/116 | 1.55 (0.77, 3.13) | 92/63 | 1.89 (0.94, 3.86) | 0.11 | 0.89 |
| ≥25 | 18/24 | 1.0 | 77/95 | 1.45 (0.67, 3.15) | 114/120 | 1.36 (0.31, 5.91) | 125/90 | 2.08 (0.47, 9.17) | 0.06 | |
| Family history of prostate cancer | ||||||||||
| Without | 20/34 | 1.0 | 92/142 | 1.40 (0.69, 2.87) | 128/181 | 1.55 (0.77, 3.13) | 106/121 | 1.89 (0.94, 3.86) | 0.11 | 0.89 |
| With | 10/4 | 1.0 | 32/19 | 1.04 (0.23, 4.64) | 49/24 | 1.36 (0.31, 5.91) | 57/16 | 2.08 (0.47, 9.17) | 0.06 | |
a
Adjusted to age and PSA screening history.