Table 1.
Patient demographics
| Characteristic | All, n = 25 (%) | mRS 0–2, n = 12 (%) | mRS > 2, n = 13 (%) | P-value |
|---|---|---|---|---|
| Age, years | ||||
| Median [first quartile, third quartile] | 60·7 [54·1, 72·0] | 61·2 [54·9, 69·9] | 60·7 [53·2, 74·1] | 1·000 |
| Mean ± standard deviation | 63·4 ± 13·2 | 62·7 ± 10·5 | 64·0 ± 15·8 | |
| Gender | ||||
| Male | 11 (44·0) | 6 (50·0) | 5 (38·5) | 0·695 |
| Female | 14 (56·0) | 6 (50·0) | 8 (61·5) | 0·695 |
| Race | ||||
| Caucasian | 22 (88·0) | 10 (83·3) | 12 (92·3) | 0·593 |
| African American | 3 (12·0) | 2 (16·7) | 1 (7·7) | |
| Baseline NIHSS* | ||||
| Median [first quartile, third quartile] | 12·0 [9·0, 17·0] | 9·0 [7·0, 11·0] | 17·0 [13·0, 18·0] | <0·001 |
| Mean ± standard deviation | 12·8 ± 4·9 | 9·1 ± 3·0 | 16·2 ± 3·8 | |
| Time from symptom discovery to treatment, hours | ||||
| Median [first quartile, third quartile] | 11·1 [8·8, 14·4] | 14·3 [10·7, 19·9] | 9·9 [8·5, 11·1] | 0·030 |
| Mean ± standard deviation | 12·4 ± 5·2 | 15·0 ± 6·0 | 10·0 ± 3·0 | |
| Time from last known normal to treatment, hours | ||||
| Median [first quartile, third quartile] | 14·2 [13·2, 18·3] | 16·2 [13·6, 21·1] | 13·5 [11·1, 17·8] | 0·123 |
| Mean ± standard deviation | 15·7 ± 4·2 | 17·1 ± 4·3 | 14·5 ± 3·8 | |
| Baseline infarct volume, cc (17 NCT and 8 MR scans) | ||||
| Median [first quartile, third quartile] | 9·1 [1·2, 22·2] | 3·3 [0·0, 8·8] | 21·6 [9·1, 61·7] | 0·001 |
| Mean ± standard deviation | 26·7 ± 46·0 | 7·6 ± 12·1 | 44·3 ± 58·4 | |
| Large vessel occlusion (LVO)† | 21 (84·0) | 9 (75·0) | 12 (92·3) | 0·322 |
| ICA occlusion‡ | 15 (60·0) | 4 (33·3) | 11 (84·6% | 0·015 |
| LVO + ICA occlusion | 13 (52·0) | 3 (25) | 10 (76·9) | 0·017 |
| History of hypertension | 21 (84·0) | 11 (91·7) | 10 (76·9) | 0·593 |
| History of diabetes | 8 (32·0) | 3 (25·0) | 5 (38·5) | 0·673 |
| Current smoker | 10 (40·0) | 3 (25·0) | 7 (53·8) | 0·226 |
| Prior stroke | 4 (16·0) | 3 (25·0) | 1 (7·7) | 0·322 |
| Prior TIA | 3 (12·0) | 3 (25·0) | 0 (0·0) | 0·096 |
| History of atrial fibrillation | 4 (16·0) | 1 (8·3) | 3 (23·1) | 0·593 |
| History of peripheral vascular disease | 1 (4·0) | 1 (8·3) | 0 (0·0) | 0·480 |
| History of PTCA, CABG, and/or MI | 2 (8·0) | 0 (0·0) | 2 (15·4) | 0·480 |
*
If baseline NIHSS is not available, the presenting NIHSS was substituted.
†
Large vessel occlusion (LVO) = TIMI 0 or 1 flow in M1 or M2, per PROACT II definition (0).
‡
ICA Occlusion = ≥95% stenosis or occlusion in internal carotid artery on side of stroke.