Table 4.
Mir-483-3p targets multiple RAS components and its functions unknown in VSMC
| miRNA | Predicted RAS Target |
Known Expression and Pathological Context |
|---|---|---|
| miR-675 | – | NA |
| miR-343 | – | NA |
| miR-669c | – | NA |
| miR-297c | – | NA |
| miR-669f | – | NA |
| miR-466g | – | NA |
| mi R-1198 | – | NA |
| miR-33 | AGTR1 | Cholesterol homeostasis in macrophages, atherosclerosis (upregulated) [62] |
| miR-188-5p | ACE-2 | Homocysteine-induced cardiac remodeling (upregulated) [63] |
| miR-483-3p | AGT, ACE-1, ACE-2, AGTR2 |
Wilms’ tumors, hepatocellular carcinoma, colorectal cancer, adrenocortical tumours, pancreatic cancer, proliferation in wounded epithelial cells (upregulated), myocardium of obesity-prone rats, melatonin synthesis in pineal gland (downregulated) [64–70] |
| miR-208a | – | Cardiac hypertrophy/diastolic dysfunction, electrical conductance, acute myocardial infarction (upregulated) [71, 72] |
| miR-218-1 | – | Vascular patterning (upregulated), gastric cancer, oral squamous cell carcinoma, glioma (downregulated) [73– 76] |
| miR-21 | – | Cardiac and pulmonary fibrosis, myocardial infarction, immune response, solid cancers (upregulated) [77] |
| miR-1187 | – | TNFα-mediate hepatic apoptosis (upregulated) [78] |
| miR-297b-3p | – | Lymphoma/carcinogenesis (upregulated) [79] |
| miR-106a | – | Malignant bronchial epithelial, human T-cell leukemia, gastric and pancreatic cancers (upregulated), colon cancer (downregulated) [80–82] |
| miR-301b | – | Colon and pancreatic cancers (upregulated) [83, 84] |
| miR-32 | – | Androgen-regulated prostate, gastric, and colorectal cancers (upregulated) [85–87] |
| miR-325 | – | Stress-induced suppression of luteinizing hormone secretion (upregulated) [88] |
| miR-467a | – | Growth regulation of mouse embryonic stem cells (upregulated) [89] |
| miR-467b* | – | Hepatic steatosis in non-alcoholic fatty liver disease (downregulated) [90] |
| miR-682 | – | Muscle regeneration (upregulated) [91] |
Ten genes known to be components of RAS were analyzed as potential targets of each of the 22 VSMC miRNAs by three target prediction programs. RAS genes predicted as a miRNA target by at least two programs is shown. A solid dash indicates that the miRNA was not predicted to target any components of RAS. NA: Not Available, Reference number is given in parenthesis.