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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Biochim Biophys Acta. 2014 Jul 10;1844(10):1729–1740. doi: 10.1016/j.bbapap.2014.07.002

Figure 1.

Figure 1

Eph-ephrin complexes are conformationally flexible, as indicated by comparing two Eph-ephrin complexes. (A) Two overlaid conformations of Eph receptors reveal the change in the secondary structure of the JK loop binding to ephrin-A2 and ephrin-B2. ephrin-A2 is not shown for clarity. (B) Starting conformations in the simulations of Eph-ephrin recognition with separated Eph receptor and ephrin ligand.