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Energy landscapes of four Eph receptors (A2, A4, B2, and B4) interacting with four ephrins (A1, A2, A5, and B2) reflect the binding tendencies between ephrins and their receptors, consistent with the promiscuity and specificity of their interactions. (A) EphA2 is sepcific to ephrin-A; (B) EphA4 is promiscus to both ephrinA and ephrin-B; (C) EphB2 is promiscus to both ephrin-A and ephrin-B; and (D) EphB4 is sepcific to ephrin-B.
