Table 3.
| receptor | Complex c | highly specific | specific |
|---|---|---|---|
| EphA2 | EphA2 ephrinA | 14.3% (2/14) | 35.7% (5/14) |
| EphA2 ephrin-B2 | 10.5% (2/19) | 15.8% (3/19) | |
| EphA4 | EphA4 ephrinA | 14.3% (2/14) | 42.8% (6/14) |
| EphA4 ephrin-B2 | 10.5% (2/19) | 36.8% (7/19) | |
| EphB2 | EphB2 ephrinA | 14.3% (2/14) | 28.6% (4/14) |
| EphB2 ephrin-B2 | 10.5% (2/19) | 36.8% (7/19) | |
| EphB4 | EphB4 ephrinA | 71.4% (10/14) | 14.3% (2/14) |
| EphB4 ephrin-B2 | 52.9% (9/17) | 17.6% (3/17) | |
| ligand | |||
| ephrinA1 | EphA ephrin-A1 | 0% (0/5) | 40% (2/5) |
| EphB eprhin-A1 | 21.4% (3/14) | 5.9% (1/14) | |
| ephrinA2 | EphA ephrin-A2 | 0% (0/5) | 40% (2/5) |
| EphB ephrin-A2 | 21.4% (3/14) | 5.9% (1/14) | |
| eprhinA5 | EphA ephrin-A5 | 0% (0/5) | 40% (2/5) |
| EphB ephrin-A5 | 21.4% (3/14) | 0% (0/14) | |
| ephrinB2 | EphA ephrin-B2 | 20% (1/5) | 0% (0/5) |
| EphB ephrin-B2 | 21.4% (3/14) | 5.9% (1/14) |
The percentages in the table are based on the counts of with the number of contact residues and their evolution entropies. Highly specific residues : entropy < 0.5 ; specific residues : 0.5 < entropy ≤ 1.0.
Some complexes are artificial. for example, EphB4 EphrinA complex. We mapped the contact residues to see if these complexes are formed, what are the evolution entropies for the residues to be involved in recognition.
We grouped the Eph and ephrin by their classes. EphA includes EphA2 and EphA4; EphB includes EphB2 and EphB4; and ephrinA includes ephrin-A1, ephrin-A2, and ephrin-A5. Therefore, for example EphA2 ephrinA is the group of EphA2 ephrin-A1, EphrA2 Ephrin-A2, and Eph ephrin-A5; and EphA ephrinA1 is the group of EphA2 ephrin-A1 and EphA4 ephrin-A1.