Table 1. Demographics and Phenotypes.
| Discovery | Replication | |||||
|---|---|---|---|---|---|---|
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| Total n=617 | EC n=277 | AA n=241 | Total n=165 | EC n=75 | AA n=70 | |
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| Age (mo) | 99.8 (42.0)a | 100.9 (45.2) | 102.6 (40.2) | 112.6 (43.4)a | 111.9 (42.2) | 110.3 (42.5) |
|
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| Sex M/F (%) | 48.5/51.5 | 49.1/50.9 | 45.6/54.4 | 43.0/57.0 | 41.3/58.7 | 44.3/55.7 |
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| Weight (kg) | 35.7 (20.7) | 33.7 (18.9) | 40.1 (23.3) | 39.2 (19.3) | 38.4 (20.8) | 39.6 (17.3) |
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| Height (cm) | 131.3 (20.1) | 129.6 (20.7) | 134.1 (19.4) | 135.9 (19.0) | 135.2 (19.5) | 136.2 (18.2) |
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| BMI (kg/m2) | 19.4 (5.5) | 18.6 (4.5)b | 20.6 (6.5)b | 20.0 (5.5) | 19.5 (5.8) | 20.3 (4.8) |
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| ASA PS (%) | ||||||
| 1 2 3 |
19.3c 77.4 3.3 |
20.9 75.1 4.0 |
15.8 81.3 2.9 |
11.5c 80.0 8.5 |
14.7 78.7 6.7 |
11.4 78.6 10.0 |
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| Morphine (mcg/kg) | 128.2 (41.4) | 132.4 (40.9)d | 118.6 (39.8)d | 123.3 (43.8) | 129.8 (43.1)e | 116.2 (46.0)e |
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| Pain ≤ 3* (%) | 20.3 | 15.7f | 26.7f | 20.5 | 18.9g | 22.1g |
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| Pain ≥ 7* (%) | 47.0 | 49.3h | 46.6h | 48.5 | 50.0i | 45.6i |
Age, weight, height, BMI and total morphine dose are reported as mean followed by SD in parentheses. Specific statistical comparisons are indicated with lettered superscripts:
p=5.61×10-4 (t-test for equal means);
p=4.38×10-5 (t-test for equal means);
p=2.34×10-3 (Fisher's exact test);
p=1.28×10-4 (t-test for equal means);
p=0.0672 (t-test for equal means);
p=3.42×103 (Fisher's exact test);
p=0.681 (Fisher's exact test);
p=0.586 (Fisher's exact test);
p=0.618 (Fisher's exact test.)
Maximum pain scores (normalized to a 0 – 10 scale) were not reported in all children: for discovery cohort, 553 subjects had consistently documented numerical scores, and for replication, 161. AA = African-American ancestry, ASA PS = American Society of Anesthesiologists' physical status, BMI = body mass index, EC = European Caucasian ancestry, SD = standard deviation.