Table 4. Top TAOK3 SNPs associated with maximum postoperative pain ≥ 7/10 in children of European Caucasian and African-American ancestry.

EC discovery cohort (n=277)								AA discovery cohort (n=241)
SNP	Gene	Minor/Major allele	MAF (cases)	MAF (controls)	OR	CI 95%	P-value	MAF (cases)	MAF (controls)	OR	CI 95%	P-value
rs795484	TAOK3	A/G	0.42	0.25	2.35	(1.56, 3.52)	4.10x10-5	0.32	0.21	1.76	(1.14, 2.71)	9.69×10-3
rs1277441	TAOK3	C/T	0.42	0.26	2.24	(1.49, 3.36)	1.03x10-4	0.34	0.23	1.71	(1.12, 2.61)	1.21×10-2

Relationship of GWAS-identified top TAOK3 SNPs for primary outcome of morphine dose with secondary outcome of high maximum pain scores. There were 132 cases with high maximum pain score ≥7 and 136 controls with maximum pain score <7 in the EC discovery cohort; 103 cases and 118 controls in the AA discovery cohort. AA = African-American, CI 95%= 95% confidence interval, EC = European Caucasian; GWAS = genome-wide association study, MAF = minor allele frequency, OR = odds ratio, SNP = single nucleotide polymorphism.