Table 2.

Selection profiles and evidence for purifying selection at human missense mutation sites

Gene	Codon position	Amino acids in humans	α	β	ω	Purifying selection LRTa	p-value
HSPB1	34	G	0.731	0	0	20.618	<0.001
	39	P	2.748	0.399	0.145	18.484	<0.001
	41	E	2.732	0.179	0.065	15.130	<0.001
	84	G	1.492	0	0	37.117	<0.001
	99	L	0.419	0	0	12.535	<0.001
	127	R	1.933	0.118	0.061	30.343	<0.001
	135	S	0.955	0	0	24.648	<0.001
	136	R	1.219	0	0	36.149	<0.001
	140	R	1.941	0.062	0.032	36.856	<0.001
	141	K	0.613	0	0	17.058	<0.001
	151	T	2.395	0.237	0.099	20.976	<0.001
	180	T	0.694	0.262	0.378	3.011	0.083
	182	P	1.855	0	0	47.288	<0.001
	188	R	2.562	0.142	0.055	31.402	<0.001
HSPB3	7	R	1.302	0.144	0.110	10.403	0.001
HSPB5	109	D	1.620	0	0	22.963	<0.001
	120	R	2.829	0	0	37.155	<0.001
	154	G	0.246	0.376	1.526	0.264	0.607
	157	R	1.172	0	0	17.843	<0.001
HSPB6	20	P	4.148	0.183	0.044	18.039	<0.001
HSPB8	141	K	0.290	0	0	4.599	0.032

^apurifying selection likelihood ratio test