FIG. 5.

Prevention of mortality and herpetic keratitis in mice immunized with CJ83193 after corneal challenge with wild-type HSV-1 strain mP. Female BALB/c mice were randomly divided into four groups and immunized with either mock-infected cell lysate (n = 28), KOS (n = 16), d27 (n = 20), or CJ83193 (n = 20) as described. Four weeks after initial immunization, both eyes of mice were challenged with HSV-1 strain mP following corneal scarification. (A) Mortality of mice following ocular HSV-1 challenge during a 30-day follow-up period. (B) Ophthalmoscopic examination of mice eyes for signs of herpetic keratitis during the same period. Individual eyes were scored for severity of keratitis. The indicated values represent the mean score ± standard error of all eyes from each group of mice.