Table 3.
| Bradykinin effect | Electrical vs. chemical AP | ||||
|---|---|---|---|---|---|
| all naïve neurons | Naive (evoked) | Post-BK (evoked) | Post-BK (evoked) | Bradykinin (spontaneous) | |
| Resting potential (mV) | −62.36 ± 2.02 (133) | − 60.6 ± 1.5 (21) | − 58.3 ± 1.9 (21)* | - | - |
| Input resistance (M Ω ) | 97.51 ± 10.09 (122) | 63.90 ± 13.96 (23) | 73.16 ± 20.61 (23) | ||
| Ramp AP (nA) | 2.45 ± 0.24 (87) | 1.96 ±0.33 (13) | 1.56 ± 0.35 (13)*** | - | - |
| Step rheo (nA) | 1.43 ± 0.11 (111) | 1.24 ± 0.12 (22) | 0.97 ± 0.15 (22)*** | - | - |
| Threshold (mV) | Ω15.73 ± 1.12 (80) | Ω16.32 ± 1.70 (24) | Ω19.02 ± 2.24 (24) | Ω 18.1 ± 4.4 (11) | Ω 45.49 ± 3.77 (11)*** |
| AP peak (mV) | 64.64 ± 0.89 (111) | 65.89 ± 1.88 (25) | 63.03 ± 1.92 (25) | 65.04 ± 3.19 (11) | 60.53 ± 1.59 (11) |
| AP rise time (μs) | 528.4 ± 40.2 (80) | 380.4 ± 33.9 (25) | 502.9 ± 50.7 (25)** | 552.9 ± 83.6 (11) | 536.8 ± 74.2 (11) |
| AP slope (max, mV/ms) | 326.9 ±18.6 (83) | 395.2 ± 29.5 (25) | 314.4 ± 27.1 (25)* | 281.9±37.6 (11) | 204.7±6.0 (11)* |
| AP slope (min, mV/ms) | −100.2 ± 8.6 (83) | − 101.6 ± 10.0 (25) | − 88.33 ± 9.12 (25)* | −70.51 ± 13.31 (11) | −71.58 ± 6.83 (11) |
| AP width (full, ms) | 4.92 ± 0.42 (79) | 5.11 ± 1.05 (24) | 4.93±0.69 (24) | 6.41 ± 5.69 (12) | 5.68 ± 0.74 (12) |
| AHP amplitude (mV) | −52.66 ± 1.21 (52) | −53.66 ± 1.82 (25) | −53.37 ± 1.55 (25) | − 51.48 ± 2.52 (12) | − 73.07 ± 1.32 (12)*** |
| AHP kinetics (tau, ms) | 26.67 ± 2.38 (86) | 30.01 ± 5.02 (25) | 31.26 ± 4.94 (25) | 45.46 ± 6.99 (12) | 75.89 ± 10.52 (12)** |