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. Author manuscript; available in PMC: 2014 Sep 9.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2013 Jan 3;33(4):718–726. doi: 10.1161/ATVBAHA.112.300329

Figure 3. Influence of MKEY treatment on AAA formation and progression.

Figure 3

Male C57BL/6 mice were treated with vehicle (n=8), 10 mg/kg MKEY (n=5) or 20 mg/kg MKEY (n=7) starting on day 3 prior to PE infusion for 17 days. AAAs were imaged by measuring infrarenal aortic diameter for each mouse using noninvasive transabdominal ultrasonography. An AAA was defined as a more than 50% increase in the aortic diameter over baseline level.

(A): Representative ultrasound images of aortae from PPE-infused mice treated with vehicle or MKEY.

(B): Mean and SD of aortic diameters. ANOVA followed by Newman-Keuls post-test, *P<0.05 and **P<0.01 between two groups.

(C): AAA incidence in PPE-infused mice treated with vehicle or MKEY. Kaplan-Meier analysis, **P<0.01 compared to vehicle-treated mice.