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. Author manuscript; available in PMC: 2015 Jul 9.
Published in final edited form as: Cell Host Microbe. 2014 Jun 26;16(1):105–114. doi: 10.1016/j.chom.2014.05.013

Figure 3. Time course of B cell clonal expansions induced by inactivated H1N1 vaccine.

Figure 3

(A) Vaccine induced B cell clonal lineage relationships during H1N1 vaccine response (complete IGH repertoires at Figure S2). Each arc represents a post-vaccination time point sub-divided into expanded (blue) and unexpanded (yellow) compartments. Lines join lineage members at later time points. Orange lines indicate that a lineage was strongly induced at the originating time point (> 0.1% of total IGH). (B) IGHV percentage mutation for strongly induced lineages. Median (red line), quartiles shown as box and whiskers and points are jittered to prevent over-plotting.