Table 1.
Genes included in PCR array
| Gene | Function |
|---|---|
| Jun | Fos and Jun dimerize to form AP-1, involved in cell proliferation, differentiation, and transformation |
| Fos | |
| PCNA, proliferating cell nuclear antigen | DNA synthesis, cell-cycle control, and DNA-damage response and repair |
| CCND1, cyclin D1 | Regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition |
| TERT1, telomerase reverse transcriptase | Maintains telomere ends, chromosomal repair |
| mycN | Transcription factor amplified or overexpressed in variety of tumors |
| cMYC | Transcription factor activated upon various mitogenic signals such as Wnt, Shh and EGF |
| gli3 | Transcription factor mediating sonic hedgehog signaling |
| SOX2 | Transcription factor with roles in embryonic development, cell fate determination, stem cell maintenance |
| Oct4 | Involved in the self-renewal of undifferentiated embryonic stem cells. |
| Klf4 | Indicator of stem-like capacity in embryonic stem cells |
| VEGF1 | Endothelial cell mitogen |
| ANGPT1, angiopoietin 1 | Involved in vascular development and angiogenesis |
| CAV1, caveolin | Scaffolding protein, possible tumor suppressor |
| Wnt5A | Secreted signaling protein, activates beta catenin transcriptional activity |
| Wnt11 | Secreted signaling protein, implicated in oncogenesis and in several developmental processes |
| SNAI2, snail2 | Transcriptional repressor involved in epithelial-mesenchymal transitions and has antiapoptotic activity. |
| TGFbeta | Member of a family of peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types |
| IGF1, insulin like growth factor | Growth and anabolic effects |
| IL2 | Cytokine regulates lymphocyte activity |
| IL10 | Anti-inflammatory cytokine |
| PTGS1, COX1, prostaglandin G/H synthase and cyclooxygenase) | Converts arachidonic acid to prostaglandin |