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. 2014 Aug 23;2:98. doi: 10.1186/s40478-014-0098-6

Figure 1.

Figure 1

Histopathological features of active and inactive hippocampal MS lesions. MS lesions are recognized by the loss of MBP immunoreactivity in hippocampal WM and/or GM areas (A,F). Active and inactive lesions were distinguished based on the presence or absence of MHC-II positive monocytes/macrophages, respectively. WM within the lesion centre (B) and at the border (C) of the active lesion presents with activated amoeboid MHC-II positive cells. The number of MHC-II positive cells in the lesion centre (D) and at the border of a GML (E) is far lower compared to WML. Moreover, LN3+ cells within the GM have a more ramified morphology. LN3+ cells within an inactive lesion are lower in number compared to active lesions and have a ramified morphology, both within the centre (G) and at the border (H) of WM, as well as in the centre (I) and at the border of (J) GM. Frames in A & F refer to hippocampal areas shown in B-E; G-J. The dashed lines indicate the border between WM (alveus and striatum) and GM (CA1). AV = alveus; Str = Striatum. Scale bar (A, F) = 500 μm. Scale bar (B-E; G-J) = 60 μm.