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. 2014 Aug 15;15(8):432. doi: 10.1186/s13059-014-0432-0

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© Jiang et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Targeted resequencing of relapse-specific mutations in diagnostic DLBCL. (A) Resequencing of UBR4 SNV (chr1:19519971, C > A) in pair 1D and 1R1. The allele frequencies of the reference sequences and the SNV in both samples 1D and 1R1 are shown. (B) Comparison of the clonal evolution pattern represented by the dominant V_HDJ_H subclone (filled square) and the genetic evolution pattern indicated by the UBR4 SNV (filled circle) of pair 1. (C) Resequencing of B2M indel (chr15:45003781–45003782) in patient pair 9 (15D1, 15D2, and 15R). (D) Comparison of the clonal evolution pattern and the genetic evolution pattern of patient pair 9.