Table 2.
Summary of common deleted regions in relapse samples
| Chromosome | Common deleted region coordinates | Sample ID | Genes | Function in B cells |
|---|---|---|---|---|
| 1 | 117064566-117131520 | 1R3, 3R, 14R | CD58 | Genetically inactivated in DLBCL to escape immune recognition [24] |
| 4 | 961371-967030 | 1R1, 2R, 13R | DGKQ | Not known |
| 13 | 111885580-111996434 | 1R1, 2R, 3R, 14R | ARHGEF7 | Guanine nucleotide exchange factor for RAC1 GTPases that plays an important role in mature B-cell development [25] |
| 15 | 40594724-40628804 | 1R1, 3R, 15R | PLCB2 | Activated by RAC1 to modulate Ca2+ signaling [26] |
| X | 155003966-155250615 | 3R, 13R, 15R | VAMP7, IL9R | IL9R activates JAK-STAT signaling in response to IL9 [29] |