FIG. 8.
SQLs are active against various HIV-resistant viruses. (A) Mutations in the reverse transcriptase (RT) gene of the three RTI-resistant strains are indicated with respect to RT amino acid numbers. Mutations that are specifically associated with the resistance to AZT, 3TC, nevirapine, or efavirenz are labeled i, ii, iii, and iv, respectively. (B) FZ41 (first bar from the left in each group) was tested on RTI-resistant HIV-1 strains. AZT (second bar) and 3TC (third bar) were used as nucleic RTIs; efavirenz (fourth bar) and nevirapine (fifth bar) were used as nonnucleoside RTIs. (C) FZ41 (white bars) and L-731988 (black bars) were tested against genetically engineered DKA-resistant strains. IC50s were determined as described in Materials and Methods.