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Effects of aaptamines 1–3 on the EGF-induced neoplastic transformation and colony formation of murine epithelial JB6 P+ Cl41 cells. Cells in a soft agar were treated with the indicated concentrations of the substances for one week. All experiments were performed in triplicate and repeated at least two times. “∗”-P < 0.05, statistically significant differences between treated and untreated control cells (Student's t-test).
