Table 1.
Anticancer activity of aaptamines 1–3 against several human cancer cell lines. Cells were treated with the indicated concentrations of the substances for 24 h. All experiments were performed in triplicate.
| Cancer type | Cell line | Compound (IC50, μM) | ||
|---|---|---|---|---|
| 1 | 2 | 3 | ||
| Monocytic leukemia | THP-1 | 161.3 ± 20.2 | 40.9 ± 9.9 | 32.2 ± 6.8 |
| Cervical carcinoma | HeLa | 151.1 ± 10.8 | 18.6 ± 1.7 | 50.7 ± 3.6 |
| Colon cancer | SNU-C4 | 267 ± 24.4 | 22.3 ± 6.9 | 35.8 ± 5.8 |
| Melanoma | SK-MEL-28 | 156.5 ± 6.7 | 35.0 ± 2.2 | 70.3 ± 3.3 |
| Breast cancer | MDA-MB-231 | 147.2 ± 3.9 | 9.1 ± 1.4 | 10.6 ± 2.8 |