Table 1.
Primary outcome of three home closed-loop studies
| Study | Duration of home closed- loop (weeks) | Closed-loop period | Population | Time spent (%) in target glucose* |
p Value | Reference | |
|---|---|---|---|---|---|---|---|
| Closed loop | Open loop† | ||||||
| APCam06 | 3 | Overnight | Adolescents | 64 (45–79) | 47 (18–70) | <0.001 | 29 |
| Angela03 | 4 | Overnight | Adults | 52.6±10.6 | 39.1±12.8 | <0.001 | 30 |
| AP@home02 | 1 | Day and night | Adults | 75 (61–79) | 62 (53–70) | 0.005 | 33 |
*Target range 3.9–8 mmol/L for overnight and 3.9–10.0 mmol/L for day and night closed-loop studies.
†Insulin pump therapy combined with real-time continuous glucose monitoring.