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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Ann N Y Acad Sci. 2014 Feb 20;1314:32–41. doi: 10.1111/nyas.12371

Figure 1.

Figure 1

Schematic model depicting the key players involved in mammalian cellular acquisition, intracellular distribution, sensing, and mobilization of copper (Cu). ATOX1, antioxidant protein 1; Atp7A and B, copper transporting ATPaseA and B; CCO, cytochrome c oxidase; CCS, copper chaperone for SOD1; Ctr1 and 2, copper transporter 1 and 2; MT, metallothionein; SOD1, Cu/Zn- superoxide dismutase; tCtr1, truncated Ctr1.