Table 1.
Effect of licochalcone B on cardiac function in rats subjected to I/R (values are means with their standard deviation, n = 8).
| Physical index | Reperfusion (%) | ||
|---|---|---|---|
| 15 min | 30 min | 45 min | |
| LVDP | |||
| Control | 96.31 ± 3.27 | 94.45 ± 4.12 | 93.67 ± 4.92 |
| I/R | 40.50 ± 4.59## | 47.18 ± 4.08## | 48.76 ± 5.88## |
| 0.5 μg/mL licochalcone B | 79.76 ± 2.06∗∗ | 78.28 ± 3.79∗∗ | 74.13 ± 5.39∗∗ |
| 1 μg/mL licochalcone B | 85.39 ± 2.73∗∗ | 82.23 ± 2.83∗∗ | 81.49 ± 3.41∗∗ |
| 3 μg/mL licochalcone B | 63.88 ± 5.54∗ | 57.46 ± 3.99∗ | 55.16 ± 2.53∗ |
| 5 μg/mL licochalcone B | 58.54 ± 3.97 | 52.96 ± 3.82 | 51.10 ± 4.28 |
| +dp/dt max | |||
| Control | 117.68 ± 2.59 | 116.79 ± 3.63 | 113.03 ± 3.71 |
| I/R | 42.26 ± 3.27## | 52.83 ± 3.41## | 52.62 ± 3.92## |
| 0.5 μg/mL licochalcone B | 68.48 ± 4.84∗ | 75.29 ± 7.46∗ | 74.59 ± 4.40∗ |
| 1 μg/mL licochalcone B | 95.11 ± 3.50∗∗ | 95.76 ± 1.84∗∗ | 92.27 ± 2.94∗∗ |
| 3 μg/mL licochalcone B | 61.05 ± 4.83∗ | 60.36 ± 4.50∗ | 57.68 ± 3.66∗ |
| 5 μg/mL licochalcone B | 55.90 ± 3.60∗ | 55.09 ± 2.10∗ | 54.22 ± 3.97∗ |
| −dp/dt max | |||
| Control | 102.69 ± 3.72 | 99.30 ± 4.93 | 97.35 ± 5.01 |
| I/R | 49.22 ± 5.88## | 56.47 ± 3.28## | 56.05 ± 4.49## |
| 0.5 μg/mL licochalcone B | 72.96 ± 5.38∗ | 74.12 ± 2.42∗ | 66.78 ± 5.68∗ |
| 1 μg/mL licochalcone B | 85.60 ± 2.40∗∗ | 83.62 ± 5.14∗∗ | 84.76 ± 7.00∗∗ |
| 3 μg/mL licochalcone B | 54.59 ± 6.85∗ | 53.50 ± 5.25∗ | 50.12 ± 5.55∗ |
| 5 μg/mL licochalcone B | 49.80 ± 4.91 | 48.27 ± 2.96 | 47.90 ± 4.25 |
| CF | |||
| Control | 107.34 ± 3.16 | 107.09 ± 3.53 | 104.18 ± 5.97 |
| I/R | 90.57 ± 8.78# | 100.72 ± 7.65# | 99.92 ± 10.00# |
| 0.5 μg/mL licochalcone B | 98.83 ± 1.78 | 98.72 ± 4.89 | 99.99 ± 3.45 |
| 1 μg/mL licochalcone B | 95.52 ± 6.18 | 97.95 ± 5.91 | 98.22 ± 7.16 |
| 3 μg/mL licochalcone B | 85.84 ± 3.91∗ | 90.73 ± 8.34∗ | 92.49 ± 7.77∗ |
| 5 μg/mL licochalcone B | 89.78 ± 5.44∗ | 90.07 ± 7.32∗ | 91.88 ± 3.67∗ |
| HR | |||
| Control | 118.13 ± 8.05 | 118.96 ± 3.81 | 122.56 ± 3.91 |
| I/R | 86.49 ± 10.97## | 78.49 ± 8.81## | 69.00 ± 3.50## |
| 0.5 μg/mL licochalcone B | 94.99 ± 8.90 | 93.01 ± 11.05∗ | 86.99 ± 1.34∗ |
| 1 μg/mL licochalcone B | 105.46 ± 8.29∗ | 100.55 ± 9.07∗∗ | 97.07 ± 4.36∗∗ |
| 3 μg/mL licochalcone B | 97.86 ± 8.53 | 89.68 ± 6.47 | 86.47 ± 5.02 |
| 5 μg/mL licochalcone B | 87.00 ± 9.40 | 80.49 ± 8.98 | 74.13 ± 3.57 |
Left ventricular developed pressure (LVDP); maximum rise velocity (+dp/dt max); maximum down velocity (−dp/dt max); coronary flow (CF); heart rate (HR). ## P < 0.01 and # P < 0.05 compared with control group; *P < 0.05 and **P < 0.01 compared with the I/R group.