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. Author manuscript; available in PMC: 2015 Feb 14.
Published in final edited form as: Nature. 2014 Jul 30;512(7513):155–160. doi: 10.1038/nature13600

Figure 3. Single Cell and Population Sequencing of a TNBC.

Figure 3

a, Frozen TNBC specimen. b, Circos plot of mutations and CNAs detected by population sequencing of the TNBC, with cancer genes on the outer ring. c, Flow-sorting histogram of ploidy distributions, showing three major subpopulations: diploid (D), hypodiploid (H) and aneuploid (A). d, Neighbor-joining tree of 50 single cell integer copy number profiles, rooted by the diploid node. e, Clustered heatmap of the nonsynonymous point mutations detected by single nuclei exome sequencing and population sequencing (P). Mutations detected in one cell are excluded.