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. 2014 Sep 9;4:6311. doi: 10.1038/srep06311

Figure 3. Structural impact of the human NAPRT1 missense mutations.

Figure 3

Val106 (A) interacts with Leu476, Cys477 and Leu478 and in the model with Met106 (B – red) the same interactions are maintained. Arg332 (C) establishes contacts with Ala328, Arg336, Phe335 and Glu372. Cys332 (D – red) loses polar contact with Glu372.