Figure 4.

Dorsal root ganglion of a rat (perfusion fixed and embedded in epoxy resin) exposed to a toxic dose (600 mg/kg) of pyridoxine administered intraperitoneally twice a day for 4 days and killed 2 days after the last exposure. Degradative change is seen in the soma of a neuron (black arrow), which progresses to necrosis manifest by satellite cell phagocytosis of an affected neuron cell body (neuronophagia) (arrowhead). There also is axonal degeneration of a myelinated dorsal root fiber within the ganglion (white arrow). Toluidine blue and safranin stain.