Figure 3:

Gene expression profiling of Naïve, M. leprae-Infected Untreated and Treated armadillo post-tibial nerves. Expression of molecular markers associated with nerve structure and function (PGP9.5 [UCHL1] PMP 22, β- tubulin, Neurofilament, NCAM, growth factors [NGF β and DLK-1,]) and inflammation (TNF-α and IFN-γ) was compared between armadillo post-tibial nerves harvested from 1) Naïve: uninfected-normal animals, 2) Infected Untreated animals, and 3) Treated, Infected animals that had received 12 months of rifampin treatment. Data was normalized using GAP3DH, and relative expression was computed by using the ΔΔCt method. Results represent mean ± SD from duplicate experiments on five animals in each group.