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Model of HSV-1-mediated suppression of cytokine expression. Accumulation of HSV IE genes correlates with induction of cytokines and chemokine expression. The data presented in this work demonstrate that two IE genes, ICP4 and ICP27, actively counteract the expression of many proinflammatory cytokines with antiviral potential by decreasing mRNA stability, a phenomenon that could potentially impede the host defense against HSV.
