Methods	RCT, DB, DD, placebo and active controlled, parallel-group 12 hour study in patients with moderate to severe pain
Participants	Post-operative dental surgery, third molar extraction Male and females Age >17 years Mean age 22 years SD 5.0 N = 202
Interventions	Lumiracoxib 400 mg, n = 50, 100 mg n = 51 Ibuprofen 400 mg n = 51 Placebo n = 50
Outcomes	Patients with >50% PR over six hours: lumiracoxib 32/50, Placebo 6/50 Time to remedication: Lumiracoxib >12 hours Placebo 2.0 hours Time to onset: Lumiracoxib 0.6 hours Placebo >12 hours
Notes	One serious adverse event due to a DVT in a placebo patient QS = 4 (R1, D2, W1)
Risk of bias
Item	Authors’ judgement	Description
Allocation concealment?	Unclear	B - Unclear

Key:

DB - Double blind

DD - Double Dummy

DVT - Deep vein thrombosis

PR - Pain relief

RCT - Randomised Controlled Trial