Skip to main content
. Author manuscript; available in PMC: 2014 Sep 9.
Published in final edited form as: Cochrane Database Syst Rev. 2011 Dec 7;(12):CD006528. doi: 10.1002/14651858.CD006528.pub2

Comparison 4. Mirtazapine versus heterocyclic antidepressants.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Primary outcome (response) at 2 weeks 2 300 Odds Ratio (M-H, Random, 95% CI) 1.14 [0.64, 2.04]
 1.1 vs Trazodone 2 300 Odds Ratio (M-H, Random, 95% CI) 1.14 [0.64, 2.04]
2 Primary outcome (response) at end of the acute-phase treatment 2 300 Odds Ratio (M-H, Random, 95% CI) 1.50 [0.95, 2.37]
 2.1 vs Trazodone 2 300 Odds Ratio (M-H, Random, 95% CI) 1.50 [0.95, 2.37]
3 Secondary outcome (remission) at 2 weeks 2 300 Odds Ratio (M-H, Random, 95% CI) 1.0 [0.36, 2.80]
 3.1 vs Trazodone 2 300 Odds Ratio (M-H, Random, 95% CI) 1.0 [0.36, 2.80]
4 Secondary outcome (remission) at end of the acute-phase treatment 2 300 Odds Ratio (M-H, Random, 95% CI) 1.38 [0.76, 2.52]
 4.1 vs Trazodone 2 300 Odds Ratio (M-H, Random, 95% CI) 1.38 [0.76, 2.52]
5 Secondary outcome (withdrawal due to any reason) 2 300 Odds Ratio (M-H, Random, 95% CI) 0.90 [0.47, 1.72]
 5.1 vs Trazodone 2 300 Odds Ratio (M-H, Random, 95% CI) 0.90 [0.47, 1.72]
6 Secondary outcome (withdrawal due to adverse events) 2 300 Odds Ratio (M-H, Random, 95% CI) 0.61 [0.25, 1.51]
 6.1 vs Trazodone 2 300 Odds Ratio (M-H, Random, 95% CI) 0.61 [0.25, 1.51]
7 Hypertension/Tachycardia 1 100 Odds Ratio (M-H, Random, 95% CI) 0.31 [0.06, 1.59]
 7.1 vs Trazodone 1 100 Odds Ratio (M-H, Random, 95% CI) 0.31 [0.06, 1.59]
8 Hypotension/Bradycardia 2 300 Odds Ratio (M-H, Random, 95% CI) 0.17 [0.03, 1.00]
 8.1 vs Trazodone 2 300 Odds Ratio (M-H, Random, 95% CI) 0.17 [0.03, 1.00]
9 Constipation 1 100 Odds Ratio (M-H, Random, 95% CI) 0.70 [0.26, 1.83]
 9.1 vs Trazodone 1 100 Odds Ratio (M-H, Random, 95% CI) 0.70 [0.26, 1.83]
10 Dry mouth/Decreased salivation 2 300 Odds Ratio (M-H, Random, 95% CI) 0.39 [0.11, 1.37]
 10.1 vs Trazodone 2 300 Odds Ratio (M-H, Random, 95% CI) 0.39 [0.11, 1.37]
11 Nausea/Vomiting/Gastric distress 1 100 Odds Ratio (M-H, Random, 95% CI) 0.68 [0.20, 2.32]
 11.1 vs Trazodone 1 100 Odds Ratio (M-H, Random, 95% CI) 0.68 [0.20, 2.32]
12 Weight gain/Increased appetite 1 100 Odds Ratio (M-H, Random, 95% CI) 4.95 [1.30, 18.81]
 12.1 vs Trazodone 1 100 Odds Ratio (M-H, Random, 95% CI) 4.95 [1.30, 18.81]
13 Weight loss/Anorexia 1 100 Odds Ratio (M-H, Random, 95% CI) 0.33 [0.01, 8.21]
 13.1 vs Trazodone 1 100 Odds Ratio (M-H, Random, 95% CI) 0.33 [0.01, 8.21]
14 Anxiety/Agitation 2 300 Odds Ratio (M-H, Random, 95% CI) 0.62 [0.19, 1.96]
 14.1 vs Trazodone 2 300 Odds Ratio (M-H, Random, 95% CI) 0.62 [0.19, 1.96]
15 Dizziness/Vertigo/Faintness 2 300 Odds Ratio (M-H, Random, 95% CI) 0.64 [0.30, 1.39]
 15.1 vs Trazodone 2 300 Odds Ratio (M-H, Random, 95% CI) 0.64 [0.30, 1.39]
16 Headache 1 100 Odds Ratio (M-H, Random, 95% CI) 0.65 [0.23, 1.87]
 16.1 vs Trazodone 1 100 Odds Ratio (M-H, Random, 95% CI) 0.65 [0.23, 1.87]
17 Sleep disturbance 1 200 Odds Ratio (M-H, Random, 95% CI) 0.42 [0.13, 1.42]
 17.1 vs Trazodone 1 200 Odds Ratio (M-H, Random, 95% CI) 0.42 [0.13, 1.42]
18 Sleepiness/Drowsiness/Somnolence 2 300 Odds Ratio (M-H, Random, 95% CI) 0.62 [0.29, 1.36]
 18.1 vs Trazodone 2 300 Odds Ratio (M-H, Random, 95% CI) 0.62 [0.29, 1.36]
19 Completed suicide 1 200 Odds Ratio (M-H, Random, 95% CI) 3.03 [0.12, 75.28]
 19.1 vs Trazodone 1 200 Odds Ratio (M-H, Random, 95% CI) 3.03 [0.12, 75.28]
20 Suicide attempt 1 200 Odds Ratio (M-H, Random, 95% CI) 2.02 [0.18, 22.65]
 20.1 vs Trazodone 1 200 Odds Ratio (M-H, Random, 95% CI) 2.02 [0.18, 22.65]