Methods	4 week randomised study
Participants	Diagnosis: DSM-IV major depression Setting: Unclear
Interventions	1. Mirtazapine: 30-45 mg/day, N = 20 2. Paroxetine: 20-30 mg/day, N = 20 3. Combination of mirtazapine and paroxetine Flexible dosing scheduling
Outcomes	The measure used for response and remission in the review: Unclear Other measures: MADRS
Notes	We were unable to retrieve usable information for the meta-analysis and to contact the author because the principal author passed away
Risk of bias
Bias	Authors’ judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Quote: “randomised” Comment: No further information provided.
Allocation concealment (selection bias)	Unclear risk	Comment: The method of concealment is not described.
Blinding (performance bias and detection bias) All outcomes	Low risk	Quote: “double-blind” Comment: No further information provided.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	No information of attrition to permit judgement is provided.
Selective reporting (reporting bias)	Unclear risk	No information to permit judgement is provided.
Free of Sponsorship bias?	Unclear risk	No information to permit judgement is provided.