Table 1.
Conditions associated with myasthenia gravis with acute exacerbation As described in the text, this table details conditions associated with the exacerbation as compared with two controls, influenza and hip joint pain, within two months of exacerbation.
| ICD-9 description | Have disease (case set, 204 patients) | Incidence (case set) | Have disease (control set, 2582 patients) | Incidence (control set) | Odds ratio | p-value |
|---|---|---|---|---|---|---|
| Carpal tunnel syndrome | 9 | 0.044118 | 2 | 7.75E-04 | 56.96 | 2.47E-09 |
| Urinary tract infection site not specified | 26 | 0.127451 | 76 | 0.029435 | 4.33 | 5.95E-09 |
| Pneumonitis due to inhalation of food or vomitus | 15 | 0.073529 | 21 | 0.008133 | 9.041 | 7.94E-09 |
| Anxiety state unspecified | 14 | 0.068627 | 22 | 0.008521 | 8.054 | 7.39E-08 |
| Unspecified essential hypertension | 53 | 0.259804 | 305 | 0.118125 | 2.199 | 9.73E-08 |
| Esophageal reflux | 19 | 0.093137 | 56 | 0.021689 | 4.294 | 8.60E-07 |
| Unspecified pleural effusion | 12 | 0.058824 | 21 | 0.008133 | 7.232 | 1.55E-06 |
| Friedlander\'s bacillus infection in conditions classified elsewhere and of unspecified site | 6 | 0.029412 | 2 | 7.75E-04 | 37.97 | 3.55E-06 |
| Thyrotoxicosis without goiter or other cause and without thyrotoxic crisis or storm | 6 | 0.029412 | 2 | 7.75E-04 | 37.97 | 3.55E-06 |
| Atrial fibrillation | 15 | 0.073529 | 41 | 0.015879 | 4.631 | 6.17E-06 |
| Other specified disorders of pancreatic internal secretion | 4 | 0.019608 | 0 | 0 | -1 | 2.80E-05 |
| Other specified idiopathic peripheral neuropathy | 4 | 0.019608 | 0 | 0 | -1 | 2.80E-05 |
| Pure hypercholesterolemia | 20 | 0.098039 | 83 | 0.032146 | 3.05 | 3.49E-05 |
| Hemorrhage complicating a procedure | 5 | 0.02451 | 2 | 7.75E-04 | 31.64 | 3.73E-05 |
| Long-term (current) use of steroids | 5 | 0.02451 | 3 | 0.001162 | 21.09 | 9.37E-05 |
| Personal history of noncompliance with medical treatment presenting hazards to health | 7 | 0.034314 | 13 | 0.005035 | 6.815 | 3.47E-04 |
| Hematoma complicating a procedure | 4 | 0.019608 | 2 | 7.75E-04 | 25.31 | 3.73E-04 |
| Adrenal cortical steroids causing adverse effects in therapeutic use | 5 | 0.02451 | 5 | 0.001936 | 12.66 | 3.73E-04 |
| Nontoxic uninodular goiter | 3 | 0.014706 | 0 | 0 | -1 | 3.87E-04 |
| Chronic lymphocytic thyroiditis | 3 | 0.014706 | 0 | 0 | -1 | 3.87E-04 |
| Personal history of malignant neoplasm of bladder | 3 | 0.014706 | 0 | 0 | -1 | 3.87E-04 |
| Personal history of malignant neoplasm of other endocrine glands and related structures | 3 | 0.014706 | 0 | 0 | -1 | 3.87E-04 |
| Embolism and thrombosis of other specified veins | 4 | 0.019608 | 3 | 0.001162 | 16.88 | 8.20E-04 |
| Depressive disorder not elsewhere classified | 14 | 0.068627 | 62 | 0.024012 | 2.858 | 9.55E-04 |
| Toxic diffuse goiter without thyrotoxic crisis or storm | 3 | 0.014706 | 1 | 3.87E-04 | 37.97 | 0.001465 |
| Unspecified idiopathic peripheral neuropathy | 3 | 0.014706 | 1 | 3.87E-04 | 37.97 | 0.001465 |
| Unspecified disorder of optic nerve and visual pathways | 3 | 0.014706 | 1 | 3.87E-04 | 37.97 | 0.001465 |
| Personal history of tobacco use | 8 | 0.039216 | 24 | 0.009295 | 4.219 | 0.001632 |
| Diabetes mellitus without complication type i not stated as uncontrolled | 8 | 0.039216 | 25 | 0.009682 | 4.05 | 0.002022 |
| Hypertrophy (benign) of prostate without urinary obstruction | 5 | 0.02451 | 9 | 0.003486 | 7.032 | 0.002323 |
| Bipolar disorder, unspecified | 4 | 0.019608 | 5 | 0.001936 | 10.13 | 0.002624 |
| Unspecified disorder of thyroid | 3 | 0.014706 | 2 | 7.75E-04 | 18.99 | 0.003465 |
| Retention of urine unspecified | 3 | 0.014706 | 2 | 7.75E-04 | 18.99 | 0.003465 |
| Other specified retention of urine | 3 | 0.014706 | 2 | 7.75E-04 | 18.99 | 0.003465 |
| Migraine unspecified without mention of intractable migraine without mention of status migrainosus | 4 | 0.019608 | 6 | 0.002324 | 8.438 | 0.004125 |
| Other pulmonary embolism and infarction | 4 | 0.019608 | 6 | 0.002324 | 8.438 | 0.004125 |
| Unspecified sleep apnea | 4 | 0.019608 | 6 | 0.002324 | 8.438 | 0.004125 |
| Anemia unspecified | 11 | 0.053922 | 53 | 0.020527 | 2.627 | 0.005828 |
| Methicillin susceptible staphylococcus aureus | 3 | 0.014706 | 3 | 0.001162 | 12.66 | 0.006558 |
| Obstructive sleep apnea (adult)(pediatric) | 3 | 0.014706 | 3 | 0.001162 | 12.66 | 0.006558 |
| Tracheostomy status | 4 | 0.019608 | 10 | 0.003873 | 5.063 | 0.015584 |
Only the 209 patients with other conditions in the preceding two months are considered, and the number of patients with the associated condition is in the column "Have disease (case set)", with the incidence rate in the following column. The control set shown is influenza, with analagous columns. Finally the odds ratio and statistics are shown. We filter out any conditions that are directly associated with myasthenia gravis (such as shortness of breath), and also any conditions occurring in fewer than three patients with the disease.