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. Author manuscript; available in PMC: 2014 Sep 9.
Published in final edited form as: Inflamm Bowel Dis. 2014 Apr;20(4):723–731. doi: 10.1097/MIB.0000000000000011

Figure 5. Correlation of microbial function with the homeostasis of CD4+ effector cells.

Figure 5

(A) Representative gating strategy for the FACS analysis of lamina propria mononuclear cells (LPMCs), showing live CD3+ CD4+ lymphocytes with intracellular staining for interleukin (IL)- IL-22 production and Foxp3 expression. (B) Frequency of CD4+Foxp3+Tregs from LPMCs of CD patients in Inflamed (red) and Non-Inflamed (blue) biopsy sites. (C) Linear regression of KEGG pathways (lipid, carbohydrate and amino acid metabolism) with the percentage of CD4+Foxp3+ present in the same biopsy location taken from CD patients. (D) Frequency of CD4+IL-22+ cells of UC patients in Inflamed (red) and Non-Inflamed (blue) biopsy sites. (E) Linear regression of KEGG pathways with the percentage of CD4+IL-22+ cells present in the same biopsy location taken from UC patients.