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. 2014 Jun 18;34(9):1522–1530. doi: 10.1038/jcbfm.2014.112

Figure 1.

Figure 1

Intraischemic ADC recovery in NPA-preconditioned animals. (A) Masks of the ischemic lesion from individual animals of the control (Con) or NPA-treated group derived from ADC maps acquired 15 (upper panel) or 45 (lower panel) minutes after the onset of MCAO. Masks are overlaid onto anatomic (T2w) images. Regions of overlap between individual animals are color-coded. Although the area of ADC reduction is similar at 15 and 45 minutes ischemia duration in controls, there is a dramatic intraischemic recovery in the NPA group. (B) Number of voxels with a significantly reduced ADC (mean±s.d.) at 15 and 45 minutes after the onset of ischemia (**P<0.01). ADC, apparent diffusion coefficient; MCAO, middle cerebral artery occlusion; NPA, 3-nitropropionic acid.