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(A & B) Shown are the rates of cleavage of the tripeptide substrate S-2366 by 6 nM (A) fXIaWT or (B) fXI-Gly184. (C & D) Cleavage of S-2366 (500 nM) by 6 nM (C) fXIa fXIWT or (D) fXI-Gly184 in the presence of varying concentrations of fIXaβ. For all panels, data points represent averages of duplicate runs.
