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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Neuropharmacology. 2014 Jun 9;85:357–366. doi: 10.1016/j.neuropharm.2014.05.041

Figure 6. Daily neonatal treatment with the specific MC4R agonist PF446687 facilitated partner preference in both sexes.

Figure 6

Daily injection with either 0.1mg/kg or 1mg/kg PF446687 did not lead to a significant weight loss in neonates (A) or juveniles (B) in comparison to vehicle (Veh)-injected controls. Prairie vole females injected with the either dose of PF446687 from PND1-7 spent significantly more time huddling with the partner over the stranger after an abbreviated 6hr cohabitation (C). Only those males injected with the high dose of PF446687 spent more time with the partner at both 24 and 48hr of cohabitation with an unprimed female (D). Asterisks indicate planned Student’s t-tests with p < 0.017.