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. Author manuscript; available in PMC: 2014 Sep 9.
Published in final edited form as: Nat Immunol. 2012 Jul 19;13(8):722–728. doi: 10.1038/ni.2366

Figure 1. Architecture of the IL-12 Cytokine Family.

Figure 1

Diagram shows a schematic of the IL12 family cytokines, their receptors and JAK-STAT signaling partners. The Greed-Red bar along the bottom depicts their functional spectrum from most pro-inflammatory (IL-23) to most inhibitory (IL-35).