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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Oral Oncol. 2014 Jun 3;50(8):746–752. doi: 10.1016/j.oraloncology.2014.05.003

Table 4.

Summary of Studies Correlating SPC Dose with C-RAD Outcomes

Study Reported SPC Dose Relationship Swallowing Outcome Measured Time Point
Levendag et al. (2008) [17] Mean dose < 51 Gy* Severe dysphagia as characterized by at least 1 of: RTOG Score Dysphagia ≥ 3, PSS≤50, MDADI≤50 and H&N35 q35–q38 Longitudinal
Feng et al. (2007) [18] V40 < 95, V50 < 90, V60 < 80* Videofluoroscopy summary score & aspiration 3 months post-RT
Teguh et al. (2008) [19] Mean dose Fiberoptic endoscopic evaluation of swallowing score ≥ 1 year post RT
Caudell et al. (2010) [20] V65 < 33* Pharyngeal stricture requiring dilation ≥ 1 year post RT
Schwartz et al. (2010) [4] V55 < 80%* Oropharyngeal swallowing efficiency (OPSE) 6, 12 and 24 months post- RT

Abbreviations: RTOG, Radiation Therapy Oncology Group, PSS, Performance Status Scale-Head Neck, MDADI, MD Anderson Dysphagia Inventory

*

Volumetric doses associated with favorable swallowing outcomes