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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Biochim Biophys Acta. 2014 Jul 30;1843(11):2620–2630. doi: 10.1016/j.bbamcr.2014.07.012

Fig. 6.

Fig. 6

Bcl3 mediates the BZ-induced IL-8 and IL-17 expression, and cIAP1 and cIAP2 inhibition in Hut-78 cells. (A) Suppression of Bcl3 mRNA (top left panel) and protein (lower left panel) levels by Bcl3 siRNA decreases viability in BZ-treated Hut-78 cells, measured by Trypan Blue exclusion (right panel). (B) Real time RT-PCR analysis of cIAP1, cIAP2 and Bcl2 mRNA levels in Hut-78 cells transfected with control siRNA (full columns) or Bcl3 specific siRNA (empty columns) and treated 24 h with 0, 10 and 100 nM BZ. (C) Real time RT-PCR analysis of IL-8 and IL-17 mRNA levels in Hut-78 cells transfected with control siRNA (full columns) or Bcl3 specific siRNA (empty columns) and treated 24 h with 0, 10 and 100 nM BZ. The values represent the mean ± SE of four experiments. Asterisks denote a statistically significant (p < 0.05) change compared to cells transfected with the corresponding control siRNA.

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