Figure 3.

At the whole-brain level, the correlation between structural and functional connectivity is reduced in patients vs. controls for the sparsity range 0.01–0.11 (A, top). Within this sparsity range, similar effects were found in all modules; effects of highest significance were found within the medial parietal module (A, module 2). For sparsity value 0.04, the connections investigated and the regression lines are given in (B) and (C) for the whole brain and the medial parietal module, respectively. Note that the reduction is SC-FC correlation is more pronounced in the medial parietal module. Furthermore, significant increases in SC-FC correlation with age were found in the patients only (solid lines).