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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Arthritis Rheumatol. 2014 Jul;66(7):1909–1919. doi: 10.1002/art.38572

Figure 1.

Figure 1

Low expression of caveolin-1 in the monocytes of healthy African Americans results in enhanced migration toward stromal cell–derived factor 1 (SDF-1). Monocytes obtained from Caucasian (C) and African American (AA) healthy donors and patients with systemic sclerosis (SSc) were characterized in terms of their expression of caveolin-1 and their migration toward SDF-1. A, Caveolin-1 levels (normalized to GAPDH loading control) as assessed by densitometry. Boxed area shows a Western blot (50 μg total protein per lane) from a typical experiment using monocyte extracts from the indicated sources. B, Monocyte migration toward SDF-1. In A and B, each data point represents a single subject; horizontal lines show the mean. C, Inhibition of monocyte migration by the caveolin-1 scaffolding domain (CSD) peptide. The lines connect the data points for each subject. ** = P < 0.01; *** = P < 0.001. hpf = high-power field.