Fig. 5.—

Structure-based sequence alignment provides a link between BLES03, SpvC, and LanL lyase. Structure-based sequence alignment of BLES03 structures (highlighted in blue), SpvC-like PTL structures (in pink), structure of eIF4-E (in yellow), and sequences of LanL-like proteins (in green). Red star: active site residues of SpvC-like PTL; blue circles: phosphotyrosine (pY)-binding residue. Consensus secondary structure and predicted secondary structure of VenL’s lyase domain are shown below the alignment. Numbered stars provide a link to same residues in figure 6A.