Table 2.
Synergism of gemcitabine/NSC109555 combination in human pancreatic cancer cells. Table 1 shows CI values obtained from experiments using the MIA PaCa-2, CFPAC-1, Panc-1 and BxPC-3 cells. These CI values were calculated by the Chou and Talalay method for drug interactions using Compusyn software for the different fractions affected (the CI values at ED50, ED75 and ED90). Values of CI<1, =1 and >1 indicate synergism, additive effects and antagonism respectively
| Combination index (CI) | |||
|---|---|---|---|
| ED50 | ED75 | ED90 | |
| MIA PaCa-2 | 0.10 | 0.06 | 0.04 |
| CFPAC1 | 0.09 | 0.14 | 0.22 |
| Panc-1 | 0.42 | 0.38 | 0.47 |
| BxPC-3 | 0.06 | 0.08 | 0.11 |