. Author manuscript; available in PMC: 2014 Sep 9.

Published in final edited form as: Fam Cancer. 2014 Jun;13(2):291–299. doi: 10.1007/s10689-013-9685-0

Table 1. Clinical Features of Hereditary Cancer Syndromes Evaluated.

Syndrome	Most Common Lifetime Cancer Risks	Onset	Management Options
Syndrome	Most Common Lifetime Cancer Risks	Onset	Risk-reducing Surgery^*	Early Detection
HBOC	Breast 40-87%	Adult	✓	✓
HBOC	Ovarian 10-44%	Adult	✓
LS	Colorectal 20-80%	Adult		✓
LS	Endometrial 15-60%	Adult	✓
FAP	Colorectal 95+%	Child		✓
MEN1	Islet cell 40-75%	Child		✓
MEN2	Thyroid 95+%	Child	✓	✓

HBOC= hereditary breast and ovarian cancer syndrome; LS = Lynch syndrome; FAP = familial adenomatous polyposis; MEN = multiple endocrine neoplasia

For the purpose of this study, FAP is classified a syndrome without a risk-reducing surgical option since the surgery is typically performed when the polyp burden becomes too high to manage endoscopically, thus it is performed at a time when the patient is already affected with disease.