Table 1.

Percent of general population participants withdrawing from TEDDY in the first year, before and after high risk for early withdrawal score notification with tailored intervention was initiated

All participants
Cohort	Risk for early withdrawal	Total N	% Withdrawn	Within-cohort P-value	Between-cohort P-value
Comparison (C)
No risk notification and	Low (score <4)	1,053	4.8		C low vs. I low: 0.161
no tailored intervention	High (score ≥4)	426	12.7	C high vs. C low: <0.0001	C high vs. I high: <0.0001
Intervention (I)
Risk notification plus	Low (score <4)	1,204	3.7
tailored intervention	High (score ≥4)	524	4.4	I high vs. I low: 0.467
US participants
Cohort	Withdrawal risk	Total N	% Withdrawn	Within-cohort P-value	Between-cohort P-value
Comparison (C)
No risk notification and	Low (score <4)	485	4.3		C low vs. I low: 0.030
no tailored intervention	High (score ≥4)	248	11.7	C high vs. C low: <0.0001	C high vs. I high: <0.0001
Intervention (I)
Risk notification plus	Low (score <4)	552	2.0
tailored intervention	High (score ≥4)	294	3.7	I high vs. I low: 0.128
European participants
Cohort	Withdrawal risk	Total N	% Withdrawn	Within-cohort P-value	Between-cohort P-value
Comparison (C)
No risk notification and	Low (score <4)	568	5.3		C low vs. I low: 0.862
no tailored intervention	High (score ≥4)	178	14.0	C high vs. C low: <0.0001	C high vs. I high: 0.002
Intervention (I)
Risk notification plus	Low (score <4)	652	5.1
tailored intervention	High (score ≥4)	230	5.2	I high vs. I low: 0.926

Abbreviation: TEDDY, The Environmental Determinants of Diabetes in the Young.

Statistical comparisons were conducted using the chi-square test.