Figure 6. NPM Is a Potential Target for the Development of Human Skin Cancers.
(A) The graph shows NPM and IKKα levels in human tissue arrays containing skin SCCs, adjacent tissues surrounding SCCs, and hyperplasia of squamous epithelium, detected using immunohistochemical staining with anti-NPM (left) or anti-IKKα antibody (right). Staining was classified as +++, ++, + and −, according to staining intensity.
(B) Human tissue sections from arrays that were immunohistochemically stained with anti-NPM or anti-IKKα antibody. Brown, positive for NPM or IKKα; blue, nuclear counterstaining; epidermis stained as +++; skin SCC stained as −; condyloma stained as −; PC, breast tissue stained with anti-NPM antibody as positive control; NC, breast tissue stained with isotype control antibody as negative control within black lines. Scale bars, 50 μm.