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. Author manuscript; available in PMC: 2014 Sep 9.
Published in final edited form as: Soft Matter. 2011 Apr;7(8):3679–3688. doi: 10.1039/C0SM01351J

Fig. 1.

Fig. 1

Calmodulin’s “hinge motion” translates into dramatic changes in hydrogel properties. (A) Calmodulin crystal structures before and after binding of a trifluoperazine (TFP) ligand (PDB: 1cll → 1lin). A central region is shown in red as a point of reference to demonstrate the hinge motion. (B) Schematic representing design of poly(ethylene glycol) (PEG) hydrogels that include calmodulin (CaM). (C) Top view of a cylindrical hydrogel before and after TFP binding, demonstrating calmodulin’s dynamic function within a hydrogel (scale bar =1 mm) (B and C from Sui et al.38, copyright Wiley-VCH Verlag GmbH & Co. KGaA. Reproduced with permission).