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Inhibition of SHP2 and SHP1 by Cryptotanshinone derivatives. (A) Chemical structures of Tanshinone I, Dihydrotanshinone, Tanshinone IIA. (B) Phosphatase assays were carried out using the indicated phosphatases as enzymes and a phospho-EGFR peptide as the substrate in the presence of various concentrations of the compounds, as described in Fig. 1B. For IC50 determinations, 5 concentrations of the compounds were tested. Results shown are mean±S.E.M. of three independent experiments.
