Table 2.
SNPs with sex-specific association P-values < 1.0 × 10−6
| Eth. | Sex | SNP | Location | Alleles (risk/alt) | RAFa | Nearest gene (distance/location within gene) | P-value | ORb (95% CI) |
|---|---|---|---|---|---|---|---|---|
| EA | M | rs2549003 | 5q31.1 | G/A | 0.39 | IRF1 (2.8 kb) | 8.90 × 10−7 | 1.33 (1.18, 1.49) |
| AA | M | rs17642749 | 10q26.11 | G/T | 0.086 | RAB11FIP2 (117 kb) | 3.57 × 10−7 | 2.97 (1.90, 4.63) |
| AA | F | rs1012307 | 2q23.3 | C/A | 0.20 | AK057517 (intronic) | 7.50 × 10−7 | 1.44 (1.25, 1.67) |
| Latino | F | rs4673659 | 2q34 | C/A | 0.72 | ERBB4 (intronic) | 9.29 × 10−7 | 1.42 (1.23, 1.64) |
| Latino | F | rs2675724 | 6q27 | A/C | 0.62 | C6orf118 (127 kb) | 1.58 × 10−7 | 1.44 (1.26, 1.66) |
| Latino | F | rs9895098 | 17p13.3 | C/T | 0.10 | RAP1GAP2 (3′ UTR) | 2.79 × 10−7 | 2.31 (1.90, 2.8) |
SNPs are ordered by sex, ancestry and genomic location. Allele frequency differences between male and female controls were non-significant (P-value > 0.05) for all six SNPs.
aRAF in the sex-specific cases.
bOR from the sex-specific cases versus pooled controls.