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. 2014 May 12;23(19):5061–5068. doi: 10.1093/hmg/ddu227

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© The Author 2014. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Genome-wide significant SNP pairs in ARIC (red) and their replication (P_int < 0.05) in FHS (purple). Each horizontal line represents an interaction between two SNPs located at the start and end of the line; two vertical lines mark the 30-kb window described in the main text; y-axis: interaction P-values in the −log₁₀ scale; x-axis: genomic location in base pair (UCSC hg19/NCBI 37.3); arrow bar showing transcription direction and location of the gene (italic) below the bar; rs3733588 is the lead GWAS SNP.